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KMID : 0960920020010020117
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 2 p.117 ~ p.121
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Gradient Echo MR Imaging of Vascular Parkinsonism: A Case-Control Study
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Bae Hee-Joon
Kim Byung-Kun
Koo Ja-Seong
Kim Hyun-Sook
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Abstract
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Background & objectives: Changes of signal intensity in the various structures of basal ganglia (BG), which can be detected by gradient echo MRI (GE-MRI), have been reported in different kinds of parkinsonism. Altered iron content in these structures may be a possible explanation of above phenomenon. Vascular parkinsonism is a kind of parkinsonian syndrome and is common. However, there have been no reports about the BG signal changes on GE-MRI in vascular parkinsonism.
Methods: We investigated the difference of signal intensity in various BG and midbrain structures between 36 patients with vascular parkinsonism, which was defined as clinical parkinsonism+evidence of relevant vascular lesions on MRI+poor or no response to levodopa, and age- & sex- matched controls. The intensity of BG on GE-MRI was graded as 0-3 relative to cortical gray matter.
Results: There were no significant differences in clinical characteristics between two groups. Among patients with vascular parkinsonism, hypointensity was observed in globus pallidus in 94.4%, in putamen in 58.3%, in head of caudate in 33.3%, in substantia nigra in 72.2%, & in red nucleus in 52.8%. There was no significant linear trend in the association between signal intensity of above structures and the presence of vascular parkinsonism (p>0.05 on Mantel-Haenszel chi-square test). However, the correlation between the degree of white matter lesions and the presence of vascular parkinsonism was statistically significant (p=0.003).
Conclusions: Our GE-MRI study fails to prove that iron content of various BG structures in patients with vascular parkinsonism is different from controls.
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KEYWORD
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Parkinsonian disorders, Magnetic resonance imaging, Gradient echo, Vascular parkinsonism
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